Note: The most current version opf PermGUI is maintained at
Welcome to Permeability Graphical User Interface (PermGUI) website.

PermGUI is a graphical user interface software which is developed for quantifying blood-brain barrier permeability
from dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) data from the well-known Patlak method.
PermGUI accomplishes this in two steps:
1) calculating T1 maps from DCE-MRI,
2) calculating permeability parameters (such as permeability coefficient Ki and plasma volume Vp) using the T1 maps.

PermGUI is freely available for research purposes.

What is needed to run PermGUI: Windows 64bit PC.

Download: Click here to download the PermGUI software.

Some publications that have utilized PermGUI:

+ O. Cetin, U. Sakoglu, R. Sood, “Software package to calculate permeability based on Patlak method,”
25th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology, #988, 2-4 October 2008,
Valencia, Spain (2008).
+ O. Cetin, "An Analysis Tool to Calculate Permeability Based on the Patlak Method," Journal of Medical Systems,
Issn: 0148-5598, pp 1-10 (2010).
+ W. Liu, R. Sood, Q. Chen, U. Sakoglu, J. Hendren, O. Cetin, M. Miyake, K-J. Liu,
“Normobaric hyperoxia inhibits NADPH oxidase-mediated metalloproteinase-9 induction in cerebral microvessels in experimental
stroke,” Journal of Neurochemistry, Vol. 107, Iss.5, pp. 1196-1205 (2008).
+ M.P. Pai, U. Sakoglu, S. Peterson, C.R. Lyons, R. Sood, “Characterization of BBB permeability in a preclinical model of
cryptococcal meningoencephalitis using magnetic resonance imaging,” Journal of Cerebral Blood Flow and Metabolism, Vol. 29,
pp. 545-553 (2009).


Copyright 2013 Unal Sakoglu, PhD